2 Effect of AGEs on the formation of type III collagen during early wound healing of periodontal defects in type 2 diabetes rats

Abstract

We created periodontal defects on the palatal roots of normal and type 2 diabetes model rat maxillary first molars in order to examine the relation between advanced glycation end products (AGEs) and type III collagen. We observed the pathology and histology of the early wound healing. The experimental group showed poor formation of type III collagen and increased amorphous blood capillary localization of AGEs in vascular endothelium. It is suggested that AGEs inhibit formation collagen and interfere with the early wound healing process.