7 A comprehensive mixture of tobacco smoke components retards orthodontic tooth movement via the inhibition of osteoclastogenesis in a rat model

Abstract

Tobacco smoke is a complex mixture of numerous components. We have shown that a comprehensive mixture of tobacco smoke components (TSCs) attenuated bone resorption through osteoclastogenesis inhibition, thereby retarding experimental tooth movement in a rat model. Histological evaluation disclosed that the attenuation was partially due to the decrease of the number of TRAP-positive osteoclastic cells in the bone marrow cavity. An in vitro study indicated that TSCs seemed to more influence preosteoclasts than osteoblasts. These results may aid in formulating predictable treatments for orthodontics and bone diseases.