2020 Volume 37 Issue 3 Pages 293-297
We investigated the characteristics and prognosis of ocular motility disorders in patients with positive anti-ganglioside antibodies who visited our hospital complaining of diplopia. We enrolled 24 patients（10 male, 14 female, mean age: 42.3 ± 23.0 years）with positive anti-ganglioside antibodies and divided them into three groups; group A: those positive for anti-GQ1b antibody alone; group B: those positive for anti-GQ1b antibody and additional anti-ganglioside antibodies,and group C: those negative for anti-GQ1b antibody. Group A comprised 3 patients, all of whom had abducens nerve palsy with spontaneous remission. Group B comprised 10patients, 90.0％with abducens nerve palsy, including 2 cases of external ophthalmoplegia, and 70.0％of which remitted spontaneously. Group C comprised 11 patients, 45.5％with abducens nerve palsy, and 45.5％of all cases remitted spontaneously, but strabismus remained in 6 cases（54.5％）, and 4 cases required strabismus surgery. The male-to-female ratios in groups A, B, and C were 1：2, 7：3, and 1：10, respectively. Group C showed a significantly higher proportion of females（P＝0.007）and high risk of persistent strabismus despite aggressive treatment.
