Optic Nerve Regeneration-Related Factors

Abstract

　Previous research has reported that nerve regeneration and visual function recovery are impossible following retinal ganglion cells and optic nerve injury. However, recent studies have described many factors that can promote or inhibit axon regeneration. Currently, several factors are shown to contribute to optic nerve regeneration under specific conditions: for example, blockade of regeneration inhibitory factors is reported to act synergistically with overexpression of regeneration stimulating factors. These findings may facilitate the establishment of novel therapeutic strategies for treatment of optic nerve injury and glaucoma