Abstract
In ABO-mismatched renal transplantation, acute hemolytic anemia is sometimes caused by donor-originated lymphocytes in the renal graft. We report a retrospective examination of renal graft irradiation for the prevention of acute hemolytic anemia in ABO-mismatched renal transplantation. From January 2011 to September 2012, three patients who were recipients of the ABO-mismatched renal transplantation underwent renal graft irradiation at our facility. Irradiation was started on the day after renal transplantation and lasted for three consecutive days. Conventional fractionated irradiation was performed in order to deliver a total dose of 4.5 Gy in 3 fractions. The follow-up periods were 25 months, 30 months, and 45 months, respectively. No patients developed acute hemolytic anemia. Renal function remained good in all patients, and no malignancy was detected in any patient. In conclusion, acute hemolytic anemia might be prevented by renal graft irradiation in ABO-mismatched renal transplantation. Long-term observation focused on renal function or secondary malignancy is required.
