Analysis for the Improvement of Inadequate Glycemic Control in Patients with Type 2 Diabetes Mellitus in Nagano, Japan

Abstract

Objectives and Methods : The present study was performed to determine whether patients with HbA1c ≥ 7.0% can show improvement with additive treatments. A total of 252 patients ≤ 75 years old with type 2 diabetes mellitus (T2DM) and with HbA1c ≥ 7.0% were enrolled in this study. The primary endpoint was a rate of achievement of HbA1c < 7.0% in 1 year.
Results : HbA1c was ≥ 7.0% (7.0%-10.1%) in all patients in the study population. Initially, mean HbA1c was 7.66%±0.59%. Thus, treatments were changed for 50.4% of patients. However, treatment was not changed in nearly half of the patients. In 3 months, mean HbA1c remained at 7.63%±0.83%, and HbA1c was < 7.0% in only 18.3% of patients. At this time point, treatments were changed in 68.3% of patients. Over 1 year, treatments were changed in a total of 86.5% of the patients. However, only 27.8% of patients had HbA1c < 7.0% within 1 year.
Conclusion : The rate of reaching the target HbA1c in 1 year was only 27.8% in our study population. This was not sufficient for the control of blood glucose (BG). Thus, greater treatment intensity and further planning to improve patient condition are required to achieve the target.