Cornelia de Lange syndrome may be associated with a high incidence of nasal polyp

Abstract

Patients with Cornelia de Lange syndrome have multiple congenital malformations, such as the typical facial appearance including down-turned mouth, convergent eyebrows and curly eyelashes, and abnormalities of the limbs, as well as mental retardation. Otorhinolaryngologic abnormalities, including hearing loss and cleft palate, are well known. Cornelia de Lange syndrome occurs in approximately 1 of every 20,000 live births. Nasal polyps in Cornelia de Lange syndrome have never been reported, but 3 our 10 cases with Cornelia de Lange syndrome had nasal polyps. Nasal polyps are rarely found in children, hence,30% is a high incidence. Accordingly, based on our findings, Cornelia de Lange syndrome may be associated with a high incidence of nasal polyp.