2005 Volume 5 Issue 1 Pages 10-16
Phenanthridine derivatives are amaryllidaceae alkaloids and have broad range of potent pharmacological activi-ties such as anti leucouma (8,9-dimethoxyphenanthridinium salts), anti PARP (phenanthridones), and carcinogenicity (ethidium bromide). Synthesis of phenanthridone derivatives has been reported during the last 50 years. We have also reported synthesis of phenanthridones by the Diels-Alder reaction of 2(1H)-quinolones having an electron-withdrawing group at 3- or 4-position acting as dienophile with diene. I will outline classifying synthesis of phenanthridines.
