Abstract
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral CD4+ CD25+ T-cell malignancy caused by human T-cell leukemia/lymphoma virus type I (HTLV-I). The ATLL cells frequently infiltrate into the epidermis and form a Pautrier's microabscess. The expression of CCR4 and its ligands TARC/CCL17 and MDC/CCL22 by ATLL cells may underlie the epidermotropism and microabscess formation.[Skin Cancer (Japan) 2009 ; 24 : 206-211]
