Abstract
We report a 74-year-old man with Paget's disease on his left nipple showing remarkable pigmentation. The patient noticed a dark brown patch on his left nipple 10 years before the first of our consultations, and the size of the lesion had been increasing. We could not give a diagnosis of Paget's disease on the histological findings of the first biopsy specimens because of poor specific findings. So a wide excision was performed, and the histological examination revealed relatively large bright cells in the epidermis, positive for cytokeratin-7, CEA, antibody immunochemical stain, which was diagnosed as Paget's disease. For 2 years after the excision and following electron beam irradiation, we found no metastasis or recurrent lesions.[Skin Cancer (Japan) 2009 ; 24 : 267-271]
