Abstract
We performed photodynamic therapy (PDT) on 30 patients with solitary actinic keratosis (AK), and reported the treatment results. We added 10 cases and report the results. The method of PDT consisted of the application of 20% ALA for 4 hrs, after which exposure to an excimer-dye laser at 630 nm was performed at a dose of 50J/cm2 3 times at weekly intervals. Therapeutic effects were assessed 1 week after PDT and atypical cells were observed in 4 patients. During a follow-up of 12 months, 3 patients relapsed. Furthermore, AK lesions were divided into 2 groups according to diameter (1cm), and the histological severity was classified according to the classification of Röwert et al. (mild : atypical keratinocytes found in basal layers of the epidermis ; moderate : extending to the lower two-thirds of the epidermis, severe : more than two-thirds of the epidermis). We finally classified them into two groups : group A (mild & moderate) and group B (severe) and compared the treatment results in each group.[Skin Cancer (Japan) 2009 ; 24 : 435-438]
