Abstract
We report a case of primary cutaneous diffuse large B cell lymphoma, leg type in a 93-year-old man. He exhibited multiple asymptomatic red nodules on his left lower leg, a subcutaneous nodule on his left thigh and a blueberry-like nodule at the extranasal site with a duration of 5 years. Histopathological examination of the left lower leg revealed a dense infiltrate of atypical lymphocytes. The overlying epidermis was spared, with a distinct grenz zone. Individual tumor cells expressed CD20 and CD79α, but were negative for CD3, CD5, CD45RO and CD30. A monoclonal immunoglobulin heavy chain gene rearrangement by PCR was revealed in the involved tissue of the left thigh. By FISH assay, reciprocal translocation of chromosomes No. 8 and 14 was revealed. On physical examination, no superficial lymphadenopathy was observed. PET and CT scans showed no evidence of visceral involvement. Although low-dose etoposide therapy was administered (50-75mg/day), tumors continued to grow, and he died 2 months later due to DIC.[Skin Cancer (Japan) 2010 ; 25 : 42-46]
