Abstract
A 28-year-old Japanese female noticed a slowly enlarging, red nodule on her right thigh about 2 weeks before her initial visit to our department. Clinical examination revealed a 1×2-cm-sized red nodule on her right medial thigh. Histologically, a dense and diffuse infiltration of CD30 and ALK-positive atypical cells was observed from the upper dermis to the subcutaneous tissue. We resected the entire tumor and her swollen right inguinal lymph node. The histology revealed tumor cells in the lymph sinuses and afferent lymphatics. FDG-PET disclosed a right intrailiac lesion, which prompted us to diagnose her condition as primary cutaneous ALCL with metastasis to the right inguinal lymph node and intrailiac area. Following this diagnosis, the patient was administered 8 courses of CHOP regimen although the right intrailiac lesion was no longer visible in the PET imaging after the initial 3 courses. The patient has remained in complete remission for 12 months.[Skin Cancer (Japan) 2010 ; 25 : 157-161]
