進行期悪性黒色腫に対するCDDP，DTIC，IFN－β併用療法の奏功性と有害反応の検討

山田 南穂; 神谷 崇文; 柳澤 健二; 肥田 時征; 米田 明弘; 廣崎 邦紀; 山下 利春; 嵯峨 賢次; 神保 孝一

doi:10.5227/skincancer.25.348

Combination chemotherapy with CDDP, DTIC, IFN-β for metastatic melanoma

Naho YAMADA, Takahiro KAMIYA, Kenji YANAGISAWA, Tokimasa HIDA, Akihiro YONETA, Kuninori HIROSAKI, Toshiharu YAMASHITA, Kenji SAGA, Kowichi JIMBOW

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Keywords: Metastatic melanoma, Sequential biochemotherapy, Combination chemotherapy

JOURNAL RESTRICTED ACCESS

2010 Volume 25 Issue 3 Pages 348-352

DOI https://doi.org/10.5227/skincancer.25.348

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Abstract

We evaluated the efficacy and toxicity of combination chemotherapy with CDDP, DTIC, IFN-β on 10 patients with metastatic melanoma. The regimen was CDDP 100mg/m² on day 1, DTIC 150mg/m² on days 1-3 and IFN-β 600×10⁴IU on days 4-8. The response rate was 30%. The severe toxicities were myelosuppression, nausea/vomiting.[Skin Cancer (Japan) 2010 ; 25 : 348-352]

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