Abstract
We describe a 72-year-old male with extramammary Paget's disease on the lower abdomen. About 1 year before, the patient had noticed a plaque on his lower abdomen. The lesion gradually increased in size. Physical examination revealed an erythematous brown plaque, 34 × 65 mm in diameter, with sharp margins. The clinical features were similar to those of Bowen's disease. Histpathologic findings revealed numerous pagetoid cells with clear and abundant cytoplasm. They were distributed individually or in small clusters within the epidermis. The nuclei of these cells appeared abnormal or irregularly shaped. Initially, we supposed pagetoid Bowen's disease and extramammary Paget's disease and malignant melanoma. Immunohistological investigation showed that the malignant cells were negative for HMB-45 or S-100, and positive for CEA and GCDFP-15. Finally, the patient was diagnosed as having extramammary Paget's disease.[Skin Cancer (Japan) 2012 ; 27 : 88-92]
