Abstract
A 75-year-old woman had recognized small subcutanous nodules on her right breast after mastitis. She presented to our hospital with breast tumors after she had three lesions removed five months ago. The elastic hard, smooth-surface tumors on her right breast had reached 23×14 mm and 8×8 mm. A skin biopsy revealed abundant deposition of large lymphoid cells with cell atypia in the dermis. Immunohistochemical findings showed these cells were CD20(+), CD79a(+), bcl-2(+), bcl-6(+), MUM-1(+). At this time we diagnosed her as having diffuse large B-cell lymphoma (DLBCL). We found diffuse fluorodeoxyglucose (FDG) uptake in her right breast tumor and right axillary lymph node by (18) FDG-positron emission tomography/computed tomography (PET/CT). The patient was treated with R-CHOP therapy (Rituximab, Cytoxan, doxorubicin, vincristine, and predonisone) for a total of 6 cycles, resulting in complete disappearance of the tumor within five months. Eight months after the therapy, there has been no recurrence of the skin lesion suggesting DLBCL.[Skin Cancer (Japan) 2012 ; 27 : 345-349]
