Abstract
We report a case of a 69-year-old-woman with a malignant peripheral nerve sheath tumor in neurofibromatosis 1. Her abdominal neurofibroma was resected in 2003, and the recurrent neurofibroma was resected again in 2007. However, in 2009, it recurred again, and rapidly increased in size. She was referred to our hospital. We resected the tumor, and diagnosed it as low grade MPNST. We carried out radical resection on the rectus abdominal muscle with a 5 cm margin from the scar and reconstructed the skin defect by mesh graft. There has been no evidence of recurrence or metastasis 3 years post operatively. We think that the neurofibroma, which is a benign tumor, might have changed into MPNST, which is a malignant tumor, as a result of several surgeries in this case.[Skin Cancer (Japan) 2013 ; 28 : 74-78]
