Abstract
We present an 87-year-old male patient who developed a malignant fibrous histiocytoma of the frontal bone with epidural invasion. The subcutaneous tumor was observed in the right forehead from which excision was carried out in another hospital. The tumor recurred one month after the operation, and we excised it including the frontal bone and dura mater. Pathological examination revealed dense proliferation of small hyperchromatic cells and large, bizarre and multinucleated cells, which showed positive stain, vimentin, CD68, and HHF35. This case was diagnosed as malignant fibrous histiocytoma. After three months had passed since the surgical treatment, local recurrence was found. Then we treated the tumor with pazopanib, which is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α/β, and c-kit. Tumor regression was observed.[Skin Cancer (Japan) 2013 ; 28 : 315-319]
