Abstract
We report a case of squamous cell carcinoma (SCC) developing from recessive dystrophic epidermolysis bullosa, generalized other (RDEB-GO). When she was 35 years old, a tumor 8 cm in diameter appeared on a skin ulcer of the right back. We performed wide excision of the SCC and right axilla lymph node dissection ; we diagnosed SCC pT2N2M0, Stage IV (UICC 2009). Three months after the operation, metastases were observed at both axilla lymph nodes, and we performed lymph node dissection. Although postoperative radiation therapy was added to the treatment, the tumor was progressive, and she died at 11 months after the operation. RDEB patients often have SCC. About twenty percent of RDEB-GO patients develop SCC before 35 years of age, and 7 die because of SCC. As growth of cancer cells is very rapid, collective and comprehensive therapy is required for better outcome of SCC in RDEB. [Skin Cancer (Japan) 2015 ; 30 : 40-43]
