2019 Volume 34 Issue 1 Pages 17-23
A 44－year－old man with a 3－year history of erythema on the chest was diagnosed with mycosis fungoides (MF). His disease was stable for three years owing to treatments with topical steroids, narrow－band UVB irradiation, and oral etretinate. However, 4 years later, tumors developed in his scalp and perianal region. He was treated with oral prednisolone, bexarotene, intravenous administration of mogamulizumab, and radiation therapy, all of which showed limited effects. One year later, as 30% of his tumor cells expressed CD30, he was started on brentuximab vedotin, which was beneficial in reducing the size of the tumors. However, new lesions developed in the pharynx and larynx a few months later. Administration of gemcitabine was not effective, and the airway of the patient narrowed owing to enlarged tumors in the pharyngolarynx. He died three months later. Pathological dissection revealed multiple MF lesions in the internal organs, along with pneumonia and sepsis.[Skin Cancer (Japan) 2019 ; 34 : 17－23]
