2019 Volume 34 Issue 1 Pages 41-45
Angiosarcoma is known as a malignant soft tissue tumor that originates from the endothelial cells of blood vessels or lymphatic vessels. Cutaneous angiosarcoma usually arises on the scalp of elderly individuals, and is characterized by rapid metastasis. A novel fusion gene NUP160－SLC43A3 was identified in 2015, and rapid tumor progression is reported in patients with tumors expressing the fusion gene.
We report a case of angiosarcoma on the right cheek of a 69－year－old Japanese man ; the tumor was positive for the NUP160－SLC43A3 fusion gene, but it showed slow progression. Although chemotherapy was highly effective for this patient, the tumor recurred on the right lower jaw eight years after his first hospital visit. The clinical significance of this fusion gene in tumor progression is still unclear, and future studies to elucidate this are warranted.[Skin Cancer (Japan) 2019 ; 34 : 41－45]
