A case of giant cutaneous squamous cell carcinoma effectively treated with a combination of chemotherapy (cisplatin and adriamycin) and radiotherapy
2019 Volume 34 Issue 2 Pages 155-159
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2019 Volume 34 Issue 2 Pages 155-159
A 71-year-old Japanese man with a giant tumor on his right lower leg was referred to our hospital. Computed tomography revealed several metastases in the right inguinal and external iliac regions. We diagnosed it as cutaneous squamous carcinoma (SCC) T3 N2 M0 stage IV. He was treated with a combination of cisplatin (CDDP) and adriamycin (ADM) concurrently with radiotherapy. We also used Mohs’ paste for bleeding and exudates from the tumor. Soon after the treatment, the tumor size was reduced, with decreased serum SCC level. After three courses of chemotherapy and radiotherapy (66 Gy, Kochi oxydol-radiation therapy for unresectable carcinomas therapy), he underwent right inguinal and external iliac lymph node dissection. Skin biopsy of the tumor region was also performed. The histopathological findings showed no malignant tumor cells in all the specimens. Total excision was considered to be the first-line treatment for SCC, and radiotherapy and chemotherapy the second-line treatment. However, no standard chemotherapy has yet been established. From the present case, we suggest that the combination of CDDP and ADM chemotherapy and radiotherapy should be recommended for metastatic SCC when total excision cannot be performed owing to metastasis or other reasons.[Skin Cancer (Japan) 2019 ; 34 : 155-159]
