Cetuximab combined with radiotherapy for locally advanced squamous cell carcinoma on the cheek with oral cutaneous fistula and trismus: a case report

Abstract

A 77－year－old woman presented to us with a 13 cm skin tumor on the left cheek with trismus. She had first noticed symptoms in the buccal mucosa of the cheek one month prior to the emergence of the rapidly growing tumor. The histopathological diagnosis of the tumor was squamous cell carcinoma. Clinical imaging revealed tumoral invasion to the circumjacent muscle tissue and bilateral cervical lymph node swelling with no distant metastasis. She received cetuximab combined with radiation therapy, followed by oral tegafur, gimeracil and oteracil. Her oral function improved with tumor regression and closure of the oral cutaneous fistula. She achieved complete clinical remission and has been disease－free for 4 years and a month.[Skin Cancer (Japan) 2020 ; 35 : 58－64]