2020 Volume 35 Issue 3 Pages 143-149
Voriconazole can cause photo－induced carcinogenesis. We report three cases of squamous cell carcinoma (SCC) associated with long－term administration of voriconazole. Case 1 : A 68－year－old man had a history of cord blood transplantation for acute myeloid leukemia. He was treated with voriconazole for pulmonary aspergillosis. Six years later, he had several lesions on his nose with keratotic erythema, which were histologically diagnosed as actinic keratosis. Some lesions underwent malignant transformation to SCC. Case 2 : A 68－year－old woman had a history of bone marrow transplantation for acute myeloid leukemia. She was treated with voriconazole for pulmonary aspergillosis. Two years later, numerous actinic keratoses appeared on the dorsum of her hands and forearms, and one of the lesions progressed to SCC. Case 3 : An 83－year－old woman was treated with voriconazole for pulmonary aspergillosis. Ten years later, erosive lesions appeared on her lower lip, which rapidly developed into nodules. Skin biopsy revealed SCC. All three cases were surgically resected ; however, two of them relapsed. Physicians should be aware of the risk of voriconazole－induced photocarcinogenesis.[Skin Cancer (Japan) 2020 ; 35 : 143－149]
