Primary cutaneous adenoid cystic carcinoma : A case report

Abstract

A 51-year-old man presented with a 3-month history of a mass on his head. The mass gradually increased in size, and an incisional biopsy was performed. He was diagnosed with an apocrine mixed tumor and underwent marginal excision. Histopathological evaluation of the resected specimen revealed biphasic tumor cells, with luminal epithelial cells that formed a luminal structure and basal cell-like cells that formed a pseudolumen surrounding basophilic mucus material. We observed a cribriform pattern of proliferation with a combination of true and false lumens, involvement of surrounding tissues, multiple mitoses, necrosis, and perineural invasion. Immunohistochemical evaluation revealed tumor cells with immunopositivity for epithelial membrane antigen, α-smooth muscle actin, and calponin. Fluorodeoxyglucose-positron emission tomography did not reveal any other neoplastic focus in the body, and the patient was diagnosed with primary cutaneous adenoid cystic carcinoma. He underwent wide excision and skin grafting, 2 months after the initial surgery. No recurrence or metastasis occurred within 2 years postoperatively.[Skin Cancer (Japan) 2021 ; 36 : 76-80]