Multidisciplinary treatment for skull－invasive cutaneous squamous cell carcinoma

Abstract

Surgery is the first－line treatment for cutaneous squamous cell carcinoma (cSCC) ; however, to date, no standard treatment strategy has been developed for locally aggressive cSCC. Therefore, in this study, we aimed to assess the efficacy of a multidisciplinary treatment approach in two patients with locally aggressive skull－invasive cSCC. In both patients, concurrent docetaxel/cisplatin/fluorouracil treatment (TPF, an induction chemotherapy regime for head and neck cancer) and radiotherapy (RT) significantly decreased the tumor size without any severe adverse events. Moreover, radical surgery after TPF－based chemo－RT (CRT) lead to complete remission in both patients. Although TPF－based CRT commonly causes severe febrile neutropenia, our multidisciplinary treatment prevented adverse effects by making suitable modifications, including the adjusting of drug dosage. Overall, our findings suggest TPF－based CRT as a potential preoperative treatment strategy for locally aggressive cSCC. [Skin Cancer (Japan) 2024 ; 39 : 20－25]