2024 Volume 39 Issue 3 Pages 237-241
A 74－year－old man had a skin tumor in the right nasal ala 1 year prior to the initial visit. However, the development of subcutaneous masses in the right preauricular area and left jaw 3 months prior prompted a visit to the local dermatologist.
Analysis of the biopsy specimen revealed basal cell carcinoma (BCC), and the patient was referred to our department. Positron emission tomography－computed tomography revealed tumors in the right lung and lymph node and bone metastases, leading to a diagnosis of non－small cell lung cancer (NSCLC) with multiple metastases. The treatment for NSCLC was prioritized. BCC was treated with palliative radiation. Durvalumab (anti－programmed death ligand－1), tremelimumab (anti－cytotoxic T－lymphocyte－associated protein－4), carboplatin, and nab－paclitaxel were administered for the NSCLC. This treatment reduced the BCC, achieving almost complete remission. This case suggests that immune checkpoint inhibitors and radiation for NSCLC were effective in controlling both the NSCLC and BCC. Although only a few reports on BCC pharmacotherapy exist, immune checkpoint inhibitors may be effective because of their high tumor mutation burden. We report this case to confirm their efficacy.[Skin Cancer (Japan) 2024 ; 39 : 237－241]
