Clear cell basal cell carcinoma of the scrotum

Abstract

In this case study, a 72－year－old male presented with a dark brown patch on his scrotum, which he first noticed approximately 15 years before his first visit. The patient experienced pain, prompting him to visit our department. Upon examination, a 2.5 cm dark brown patch was observed on his scrotum. Basal cell carcinoma (BCC) was suspected, and a skin biopsy was performed. Diagnosis confirmed BCC, and the tumor was resected with a 5 mm margin from the lesion. We observed dense foci of varying sizes contiguous with the epidermis and extending into the muscle layers. These foci comprised basal cell－like and atypical cells with a prominent endoplasmic reticulum. Based on these findings, the patient was diagnosed with clear cell basal cell carcinoma (ccBCC). Histopathological findings of adjacent nodular BCC and ccBCC are rare. No recurrence or metastasis was observed during 1 year and 6 months follow－up. This case provides an opportunity to discuss the histopathology of ccBCC, with a particular focus on the mechanisms underlying its development.[Skin Cancer (Japan) 2025 ; 40 : 11－16]