Abstract

A 17-year-old Japanese male was referred to our clinic because of growing pigmented nail band of his left great toenail, which appeared after an accidental trauma 5 years ago and spread gradually. Physical examination revealed cracking of the left great toenail and a subungual nodule.
The diagnosis of melanoma was made based on histological and immunohistological examination of the excisional biopsy specimen. Tumor cells were immunoreactive to HMB-45. His left great toe was amputated. He received seven cycles of a combination chemotherapy with DTIC, ACNU, VCR, and IFN-β. No recurrence has been observed for 2 years.