Abstract

We report a case of malignant melanoma in the right conjunctiva and osteosarcoma on the right lower leg with Werner's syndrome.
He has several symptoms typical to Werner's syndrome. He received the right leg amputation for osteosarcoma at the age of 50-year-old. He became aware of a black tumor in the right conjunctiva. Histopathological examination of these two tumors revealed typical osteosarcoma and melanoma, respectively. Although, sixty-nine multiple carcinomas including melanoma have been reported only two patients who have osteosarcoma and melanoma were reported, as cases associated with Werner's syndrome.