Abstract

A 82-year-old female with squamous cell carcinoma (SCC) is reported. The tumor (#1) presented as a 1cm φ sized, riled, pigmented nodule with blackish scale on the right knee. After 2 months, another tumor (#2) presented as a 3cm φ sized, oval shaped, irregurar borderd subcutaneous nodule on the right thigh. We think #2 tumor is metastasis of #1 tumor. Because the biopsy of #1 tumor suggested SCC by hematoxylin-eosin staining, we excised the #1 & #2 tumors as one block with 3-5cm of margin. The immunohistochemistry revealed staining for keratin but not for vimentin at #1 tumor. But at #2 tumor staining for vimentin but not for keratin, suggesting that #2 tumor had originated from the mesenchyma, and also the histopathlogy by hematoxylin-eosin staining showed tumor like malignant fibrous histiocytoma. The definite diagnosis was difficult. However, it is difficult to think another malignant tumor appered on the right leg at the same time, and spindled SCC sometimes have displayed abnormal expression in the immunohistochemistry. Consequently, we think these tumors are SCC with mesenchymal metastasis.