Abstract

Squamous cell carcinoma (SCC) arising in scar tissues was reviewed in 7 patients treated at National Sapporo Hospital between 1994 and 1999. The mean age at diagnosis was 65.9. There were 5 men and 2 women. The anatomical site of the lesions were lower limb (4), upper limb (2), and head (1) . 4 SCCs arose from scars due to burns, 2 arose from scars related to trauma, and 1 arose from fistules due to chronic osteomyelitis. The mean interval from initial injury to diagnosis was 52 years. At the time of diagnosis 2 patients were in Stage II, and 5 were in Stage III. Death resulted in 4 of the 7 patients. The mean duration from diagnosis to death was 20 months. Immunohistochemically detected p53 protein overexpression seemed correlated with a reduced survival time.
A retrospective analysis was performed in patients with scar tissue carcinoma reported in Japan between 1974 and 1998. There were 258 patients, which consisted of 179 men and 79 women. The mean age at diagnosis was 55.3. The anatomical site of the lesions were lower limb (95), head (64), upper limb (48), and trunk (15) . The mean interval from initial injury to diagnosis was 37.2 years. At the time of diagnosis 4 patients were in Stage I, 25 were in Stage II, 29 were in Stage III, and 3 were in Stage IV.