Abstract
We report a case of advanced melanoma with hypercalcemia due to parathyroid hormone-related protein (PTHrP) secretion. A 40-year-old man had noticed a nodule on his left foot about 20 years previously. The size had increased quickly from January 1998. When he was admitted our hospital on May 1998, the size of lesion was 30×30 mm. We excised the tumor with the diagnosis of malignant melanoma. And inguinal lymph node dissection and chemotherapy were added.
On March 1999, he developed intransit metastasis on his left thigh. From September 1999 the serum calcium were increased. Laboratory data were as follows: serum calcium, 7.1mEq/l; C-terminal PTHrP, 133.8 pmol/l (13.8-55.3 pmol/l); intact PTH, <10 pg/ml (10-64pg/ml). It is very likely that PTHrP production by melanoma caused hypercalcemia in this patient. [Skin Cancer (Japan) 2000; 15: 246-249]
