Abstract
We report the efficacy of combination chemotherapy of low-dose cisplatin and fluorouracil (low-dose CF: cisplatin: 5-10mg/body, day1-5 (or 1-7), fluorouracil: 800-1000mg/body, dayl-5 or 1-7) for extramammary Paget's disease. Low-dose CF was given to seven patients with metastatic lesions. There were 5 males and 2 females with an age range of 54-91; the median was 74 years. Toxicities including renal impairment and neutropenia were mild and reversible. Partial response was seen in 3 cases (duration: 4, 5, 6 months) . Bone pain by metastasis and edema of the skin were also improved in some patients. We concluded that this protocol may be considered in the patients with advanced extramammary Paget's disease. We also review recent evaluation of therapeutic regimens for extramammary Paget's disease and sweat gland carcinoma. [Skin Cancer (Japan) 2003; 18: 93-98]
