Abstract
We reported a case of subcutaneous extramedullary hematopoiesis (EMH) in myelofibrosis (MF) . A 58-year-old woman diagnosed with MF had noticed multiple subcutaneous nodules on her neck, chest and back one month before. She visited our office on September 6th, 2002, because her nodules gradually increased in size. The white blood cell count was 102, 450/μl with metamyelocytes 3%, myelocytes 8%, blasts 1% and nucleated RBC were shown in peripheral blood. An abdominal CT scan showed swelling of the liver, spleen and kidney. Histopathology of subcutaneous tumor revealed proliferation of hematopoietic cells, erythroid series, myeloid series and megakaryocytic series. The diagnosis of subcutaneous EMH with MF was established. This case was treated with hydroxycarbamide. We analyzed 11 such cases in Japan. [Skin Cancer (Japan) 2003; 18: 329-333]
