Skin Cancer
Online ISSN : 1884-3549
Print ISSN : 0915-3535
ISSN-L : 0915-3535
A case of Merkel cell carcinoma
Kaori TSUJI, Yasuyuki NAKAJIMA, Rui MATSUOKA, Makiko ICHIKAWA, Naoki YOSHIZAWA, Akira SUGAMATA, Ryo SAKURADA, Kiyoshi KOIZUMI, Makoto MOCHIZUKI, Tetsuo NAGATANI
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Keywords: Merkel cell carcinoma, Spontaneous regression
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2005 Volume 20 Issue 1 Pages 99-103

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Abstract
We reported a case of Merkel cell carcinoma which regressed spontaneously following an incisional biopsy. A 68-year-old female patient visited our department complaining of a reddish nodule on her left cheek that had grown in size in the three months prior to her visit. The biopsy specimen revealed large tumor cells with scanty cytoplasm and round nuclei tightly packed in sheet and trabecular patterns. The immunohistochemistry of the specimen indicated that it was S-100protein-, synaptophysin-, chromogranin A-, and cytokeratin-positive. The patient was diagnosed as having Merkel cell carcinoma. The biopsy revealed a dense, inflammatory cellular mass consisting of lymphocytes and histiocytes surrounding apoptotic tumor cells. The tumor regressed spontaneously within the month following the biopsy. [Skin Cancer (Japan) 2005; 20: 99-103]
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