Abstract
We reported a case of extramedullary plasmacytoma of the testis, with a subsequent development of cutaneous tumor lesions. A 78-year-old man presented with a swelling of the scrotum, cutaneous tumors on his chest and abdomen. In addition, bilateral blepharoptosis and left oculomotor nerve palsy were seen. Head CT revealed a lesion, localized from pituitary fossa to sphenoid sinus. Histopathological findings showed that both testicular and cutaneous tumors were composed of many plasma cells, which were immunohistochemically positive to CD38 and CD79 α, but negative to CD20. Bone marrow biopsy disclosed normal findings and no neoplastic cell. We diagnosed this case as an extramedullary plasmacytoma of the testis origin, which developed subsequently cutaneous tumors. Therapy with radiotherapy and chemotherapy was performed, and the cutaneous tumors disappeared. However, local recurrence with disseminated cutaneous tumors occurred after 9 months. Then, a combined therapy with surgical excision, radiotherapy, and chemotherapy was performed, which resulted in a disappearance of the disseminated, cutaneous tumors. [Skin Cancer (Japan) 2005; 20: 166-170]
