Abstract
We reported two cases of melanoma with gastrointestinal tract metastasis. The first case was a 72-year-old woman who underwent resection of acral lentiginous melanoma (tumor theckness: 2.5 mm) on her right medial malleolus in 1998. She received elective right inguinal lymphadenectomy followed by 6 courses of DAVFeron therapy. Two years later, umbilical metastasis was resected. The multiple organ metastases were found and treated by 2 courses of DAC-Tam therapy in 2001. In December 2001, she presented with severe anemia, and endoscopy revealed continuous hemorrhage caused by duodenal metastasis. She underwent hemostasis by transarterial embolization. She died from multiple organ failure in January 2003. The second case was a 51-year-old woman who underwent resection of superficial spreading melanoma (tumor thickness: 0.9 mm) on her left chest 7 years previously and who presented with left axillary lymph node metastasis. Endoscopy revealed multiple amelanotic polyps in her stomach, which were resected in July 2002 and treated by a course of DAC-Tam+Feron therapy. Lung metastasis was found 3 months after the resection and the patient died in January 2003. [Skin Cancer (Japan) 2006; 21: 376-379]
