Abstract
A 79-year-old man noticed an asymptomatic eruption on the right axilla 13 years ago. The lesion had rapidly enlarged irrespective of the treatment with topical corticosteroids and UVB-irradiation for 2 years. On examination, a poikilodermatous lesion was present on the right axilla. A biopsy specimen showed a band-like infiltrate of atypical medium-to-large lymphocytes in the upper dermis. More than 70% of these cells were positive for CD3, CD4, CD7 and CD45RO. A Southern blotting analysis of DNA from the lesional skin revealed rearrangement of the T cell receptor gene. No lymphoma involvement was apparent in internal organs other the skin. On the basis of these findings, the present case was diagnosed as unilesional mycosis fungoides, stage IA. A complete remission of the disease was achieved after local (total 30 Gy) and additional total skin electron beam irradiation (total 30 Gy). [Skin Cancer (Japan) 2007; 22: 68-71]
