Abstract
We report a case of a malignant peripheral nerve sheath tumor (MPNST) with NF1.
A 63-year-old man had multiple subcutaneous neurofibromas for years. In 2006, when he was 63 years old, one of the neurofibromas on his back became enlarged and ulcerated. On histolosical examination, the new tumor occupied the dermis in a neurofibroma. The tumor cells were atypical with premorphic nuclei and were positive for S-100 protein. We diagnosed MPNST which comprised part of a neurofibroma.
Cutaneous MPNST is rarer than its deep form. Cutaneous MPNST has a better prognosis than its deep form. But approximately 60% of the cases have local recurrence. [Skin Cancer (Japan) 2007; 22: 290-292]
