Hifu no kagaku
Online ISSN : 1883-9614
Print ISSN : 1347-1813
ISSN-L : 1347-1813
CASE REPORT
Six Cases of Photosensitive Disorders Probably Due to Hydrochlorothiazide
Eriko TANAKA, Toshinori BITO, Eriko MASUOKA, Ryusuke ONO, Hideki SHIMIZU, Youzou YAMADA, Masahiro OKA, Chikako NISHIGORI, Shimano IKEMURA
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Keywords: anti-hypertensive, hydrochlorothiazide, combination tablet, photosensitivity
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2011 Volume 10 Issue 2 Pages 133-140

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Abstract
We report six patients who developed photosensitivity caused by fixed-dose combination tablets of Angiotensin II Receptor Blocker (ARB) and hydrochlorothiazide. Photo-testing with UVA or UVB radiation revealed photosensitivity to UVA in all patients. Photopatch testing was performed in five patients after informed consent was obtained. Four of the five patients showed positive reactions to hydrochlorothiazide in a photopatch test. The eruptions totally cleared after discontinuation of hydrochlorothiazide together with avoidance of sun exposure in four cases, while two patients, who had been taking hydrochlorothiazide for a longer period even after the onset of photosensitivity, developed melanoleukoderma. We suggest that these six cases of photodermatitis might have been induced by photosensitivity due to hydrochlorothiazide.Skin Research, 10: 133-140, 2011
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© 2011 Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association
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