How to use calcineurin inhibitors

Abstract

Calcineurin inhibitors used for the treatment of atopic dermatitis contain tacrolimus ointment and cyclosporine. Guidelines in the USA and Europe recommend the use of tacrolimus ointment as maintenance therapy as well as induction therapy. Recent studies reported the effectiveness of intermittent therapy for flare prevention with two- or three-times weekly applications of tacrolimus in stabilized atopic dermatitis. Cyclosporine for the treatment of atopic dermatitis has been covered by health insurance since October 2008 in Japan. Cyclosporine can be administered p.o. to adult patients with severe and recalcitrant atopic dermatitis. According to the guidance, the use of cyclosporine can be repeated intermittently; however, it is necessary to discontinue it within the first 3 months of initial use (or resuming use).Skin Research, Suppl. 18: 9-12, 2012