Abstract
We analyzed the S100A9 protein expression level during wound healing in mouse excisional wounds applied basic fibroblast growth factor (bFGF). We prepared 6mm, round, full-thickness wounds on the back skin of mice and applied bFGF (1.0μg/cm2) once daily for three days. The mRNA level of TNF-α and IL1β in granulation tissues extracted from the bFGF-applied group was determined higher than from the vehicle group by quantitative RT-PCR. The mRNA level of S100A9 extracted from the bFGF-applied group and vehicle group on day 5, day 7, and day 11 was expressed three times higher than in the vehicle group (p=0.0397). The S100A9 protein in granulation tissues from the bFGF-applied group was increased more than that from the vehicle group. We speculate that S100A9 protein plays an important role in wound healing, particularly in the inflammatory reaction.Skin Research, Suppl. 22: 7-12, 2015
