Abstract
A 36-year-old woman at 32 weeks' gestation of her sixth pregnancy was admitted to our hospital. She had been diagnosed with pruritic urticarial papules and plaques of pregnancy (PUPPP) during her second pregnancy when 27 years old. Erythematous macules with itching had appeared on her abdomen at week 28 of her pregnancy, and had gradually spread across her entire body. At the first visit, edematous erythemas with severe itching on her abdomen, and pruritic erythematous papules on her extremities were observed. Histopathological findings revealed perivascular mononuclear infiltrates in the upper and mid-dermis. Based on these findings, PUPPP was diagnosed. Eruptions and itching were improved gradually by oral and topical corticosteroids. She delivered a healthy female baby at week 37, and her pruritus and eruptions disappeared within 7 weeks after the delivery. PUPPP is a benign pruritic inflammatory skin disorder that usually affects primigravidae in their third trimester of pregnancy. Recurrence of PUPPP in subsequent pregnancies is rare, and this is the first report in Japan.Skin Research, 14: 171-174, 2015
