Abstract
A 41-year-old female was referred to our dermatology department with generalized erythema, which had occurred after she had started to take oral carbamazepine. She had also developed a fever and cervical lymphadenopathy. As drug-induced hypersensitivity syndrome (DIHS) was suspected, she was given high-dose oral prednisolone (60mg/day). Despite corticosteroid treatment, she continued to exhibit clinical symptoms, including eruptions, hypogammaglobulinemia, and abnormal serum levels of amylase and lipase. A skin patch test with carbamazepine produced a positive result, whereas a drug-induced lymphocyte stimulation test with carbamazepine only produced a positive result in the early phase of the disease. In this case, cytomegalovirus (CMV) might have been responsible for the patient's persistent clinical symptoms because we did not detect the reactivation of human herpesvirus-6 during the patient's hospitalization, while she exhibited a continuously high anti-CMV-IgM titer.Skin Research, 15: 327-331, 2016
