2019 Volume 18 Issue 2 Pages 110-115
We report a 60-year-old man with a 2-month history of painful undermining genital ulcer on the glans. Histopathological examination demonstrated an ulcer and dense dermal inltrate composed mainly of plasma cells. He was diagnosed with plasmocytosis circumoricialis, and successfully treated using topical tacrolimus ointment. The pathogenesis of this disease is considered to be irritation due to the retention of urine, smegma, and scales induced by phimosis. This disease may also be due to immune response by T cells leading to activation of the humoral immune response mediated by B cells because there are several case reports successful treatment using calcinurin inhibitors. In our case, phimosis was not observed. However, the patient had polyarteritis nodosa,in which T cells and plasma cells are easily activated. The undermining genital ulcer was suspected to have been induced by activated T cells and plasma cells due to polyarteritis nodosa, and was healed following the suppression of T cells by tacrolimus. Skin Research, 18 : 110-115, 2019
