Two Cases of Gastroenteritis Occurring during the Course of IgA Vasculitis

Abstract

We report two cases of gastroenteritis during the course of IgA vasculitis. Case 1: A 25-year-old woman developed purpura on both lower legs 4 days before her rst visit to our hospital. We diagnosed the purpura as IgA vasculitis by histopathology of the skin, and diamino-diphenyl sulfone (75 mg/day) was started. The purpura subsided once, but recurred on both lower legs. She exhibited abdominal pain, bloody stool, and vomiting. Abdominal computed tomography and colonoberscopy (CF) were performed, revealing enteritis in the small intestine, but the bleeding source was not found. Prednisolone improved the purpura and abdominal symptoms. Case 2 : A 60-year-old man had purpura and joint pain on both legs 3 days before his rst visit to our hospital. He was admitted to our hospital because the purpura spread, and he developed vomiting and diarrhea. We diagnosed the purpura as IgA vasculitis by histopathology of the skin, and diamino-diphenyl sulfone (75 mg/day) was started. After 5 days of hospitalization, he exhibited upper abdominal pain. Abdominal computed tomography, esophagogastroduodenoscopy, and CF were performed, and gastroenteritis was observed in the stomach, small intestine, and colon. Methylprednisolone pulse therapy improved the abdominal symptoms, and prednisolone improved the purpura. As we were able to observe gastrointestinal lesions associated with IgA vasculitis throughout the digestive tract,endoscopic examinations are useful for nding gastrointestinal lesions. Skin Research, 18 : 85-93, 2019