2019 Volume 18 Issue 4 Pages 204-210
Primary focus resection and sentinel lymph node biopsy were performed on a 50-year-old female under the diagnosis of primary malignant melanoma of the left lower abdomen (stage IIC T4bN0M0). In the extirpated left inguinal lymph node, metastasis from malignant melanoma was detected and the postoperative stage was evaluated as IIIC T4bN3M0. As postoperative chemotherapy, 5 courses of DAV-Feron therapy were administered and nivolumab (2mg/kg, every 3 weeks) was started. Computed tomography (CT) after the 8th course of nivolumab therapy revealed 9th right costal bone and multiple skin metastases. Topical radiotherapy at the site of bone metastasis and vemurafenib were started. Edematous erythema with vesiculation, which was consistent with the irradiated site,developed 10 days after starting vemurafenib, and diffuse systemic stigmas and red papules appeared thereafter. Considering drug exanthema, a steroid was administered. At the irradiated site, there was marked histological change, which is not routinely observed at a standard radiation dose,suggesting the radiation-enhancing effects of vemurafenib. Skin Research, 18 : 204-210, 2019
