2020 Volume 19 Issue 4 Pages 227-232
A 13-year-old girl presented with a single 8 mm red-colored, round, firm, painless, mobile nodule on the palmar side of her left ring finger. The overlying epidermis was normal. The lesion developed when she was 3 years old and it gradually increased in size proportional to her growth. Under the clinical suspicion of a neurofibroma, the lesion was surgically excised ; excision was performed to the depth of the superficial fat tissue. Histopathologically, the lesion was an unencapsulated, dense, and fibrous nodule within the dermis composed of a mixture of bland spindled and epithelioid cells with a poor atypical pattern in an extensively hyalinized stroma. A benign spindle cell tumor was diagnosed. Immunohistochemical staining was positive for epithelial membrane antigen, and the patient was diagnosed with sclerosing perineurioma (sclerosing PN) based on her clinical symptoms and pathological findings. Sclerosing PN often grows without pain,and it commonly develops on the fingers and in the palms of young men. Histopathological findings,including those of immunohistochemical staining, are useful for diagnosis. In our case, the clinical characteristics and pathological findings were consistent with the age, site of onset, and size,although it was not considered as a differential diagnosis during the first consultation. In young patients with nodules in the palms and fingers, sclerosing PN should be considered as a differential diagnosis and immunohistochemical staining of tissue sections should be performed. Skin Research, 19 : 227-232, 2020
