CASE REPORT
A Case of Pagetoid Bowen’s Disease
2022 Volume 21 Issue 2 Pages 86-90
Details
2022 Volume 21 Issue 2 Pages 86-90
A 75-year-old female presented with an erythema on the right waist since about a year before. The first skin biopsy revealed pale cells in the upper layers of the thickened epidermis. There was slight parakeratosis. Extramammary Paget’s disease was suspected by her previous doctor. A rebiopsied specimen revealed atypical keratinocytes and scattered dyskeratotic cells with a loss of polarity throughout the thickened epidermis. There were atypical pagetoid cells with pale cytoplasm in the middle to upper epidermis. Histochemically and immunohistochemically, tumor cells showed PAS (＋) (diastase-labile), Alcian blue (−), CK5/6 (＋), CAM5.2 (−), CEA (−),GCDFP15 (−), and S-100 protein (−). We diagnosed the present case as pagetoid Bowen’s disease. Histochemical and immunohistochemical approaches were efficacious for the definitive diagnosis of pagetoid Bowen’s disease. Skin Research, 21 : 86-90, 2022
